Diversity and evolution of effector loci in natural populations of the plant pathogen Melampsora lini.
Identifieur interne : 000129 ( Main/Exploration ); précédent : 000128; suivant : 000130Diversity and evolution of effector loci in natural populations of the plant pathogen Melampsora lini.
Auteurs : Luke G. Barrett [États-Unis] ; Peter H. Thrall ; Peter N. Dodds ; Marlien Van Der Merwe ; Celeste C. Linde ; Gregory J. Lawrence ; Jeremy J. BurdonSource :
- Molecular biology and evolution [ 1537-1719 ] ; 2009.
Descripteurs français
- KwdFr :
- Basidiomycota (classification), Basidiomycota (génétique), Basidiomycota (physiologie), Lin (microbiologie), Plantes (microbiologie), Polymorphisme génétique (génétique), Protéines fongiques (classification), Protéines fongiques (génétique), Variation génétique (génétique), Évolution moléculaire (MeSH).
- MESH :
- génétique : Basidiomycota, Polymorphisme génétique, Protéines fongiques, Variation génétique.
- microbiologie : Lin, Plantes.
- physiologie : Basidiomycota.
- classification : Basidiomycota, Protéines fongiques, Évolution moléculaire.
English descriptors
- KwdEn :
- MESH :
- chemical , classification : Fungal Proteins.
- classification : Basidiomycota.
- genetics : Basidiomycota, Fungal Proteins, Genetic Variation, Polymorphism, Genetic.
- microbiology : Flax, Plants.
- physiology : Basidiomycota.
- Evolution, Molecular.
Abstract
Genetic variation for pathogen infectivity is an important driver of disease incidence and prevalence in both natural and managed systems. Here, we use the interaction between the rust pathogen, Melampsora lini, and two host plants, Linum marginale and Linum usitatissimum, to examine how host-pathogen interactions influence the maintenance of polymorphism in genes underlying pathogen virulence. Extensive sequence variation at two effector loci (AvrP123, AvrP4) was found in M. lini isolates collected from across the native range of L. marginale in Australia, as well as in isolates collected from a second host, the cultivated species L. usitatissimum. A highly significant excess of nonsynonymous compared with synonymous polymorphism was found at both loci, suggesting that diversifying selection is important for the maintenance of the observed sequence diversity. Agrobacterium-mediated transient transformation assays were used to demonstrate that variants of both the AvrP123 and AvrP4 genes are differentially recognized by resistance genes in L. marginale. We further characterized patterns of nucleotide variation at AvrP123 and AvrP4 in 10 local populations of M. lini infecting the wild host L. marginale. Populations were significantly differentiated with respect to allelic representation at the Avr loci, suggesting the possibility of local selection maintaining distinct genetic structures between pathogen populations, whereas limited diversity may be explained via selective sweeps and demographic bottlenecks. Together, these results imply that interacting selective and nonselective factors, acting across a broad range of scales, are important for the generation and maintenance of adaptively significant variation in populations of M. lini.
DOI: 10.1093/molbev/msp166
PubMed: 19633228
PubMed Central: PMC2767095
Affiliations:
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Lawrence</name></author><author><name sortKey="Burdon, Jeremy J" sort="Burdon, Jeremy J" uniqKey="Burdon J" first="Jeremy J" last="Burdon">Jeremy J. 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Here, we use the interaction between the rust pathogen, Melampsora lini, and two host plants, Linum marginale and Linum usitatissimum, to examine how host-pathogen interactions influence the maintenance of polymorphism in genes underlying pathogen virulence. Extensive sequence variation at two effector loci (AvrP123, AvrP4) was found in M. lini isolates collected from across the native range of L. marginale in Australia, as well as in isolates collected from a second host, the cultivated species L. usitatissimum. A highly significant excess of nonsynonymous compared with synonymous polymorphism was found at both loci, suggesting that diversifying selection is important for the maintenance of the observed sequence diversity. Agrobacterium-mediated transient transformation assays were used to demonstrate that variants of both the AvrP123 and AvrP4 genes are differentially recognized by resistance genes in L. marginale. We further characterized patterns of nucleotide variation at AvrP123 and AvrP4 in 10 local populations of M. lini infecting the wild host L. marginale. Populations were significantly differentiated with respect to allelic representation at the Avr loci, suggesting the possibility of local selection maintaining distinct genetic structures between pathogen populations, whereas limited diversity may be explained via selective sweeps and demographic bottlenecks. Together, these results imply that interacting selective and nonselective factors, acting across a broad range of scales, are important for the generation and maintenance of adaptively significant variation in populations of M. lini.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19633228</PMID><DateCompleted><Year>2009</Year><Month>12</Month><Day>17</Day></DateCompleted><DateRevised><Year>2019</Year><Month>01</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-1719</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>11</Issue><PubDate><Year>2009</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Molecular biology and evolution</Title><ISOAbbreviation>Mol Biol Evol</ISOAbbreviation></Journal><ArticleTitle>Diversity and evolution of effector loci in natural populations of the plant pathogen Melampsora lini.</ArticleTitle><Pagination><MedlinePgn>2499-513</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/molbev/msp166</ELocationID><Abstract><AbstractText>Genetic variation for pathogen infectivity is an important driver of disease incidence and prevalence in both natural and managed systems. Here, we use the interaction between the rust pathogen, Melampsora lini, and two host plants, Linum marginale and Linum usitatissimum, to examine how host-pathogen interactions influence the maintenance of polymorphism in genes underlying pathogen virulence. Extensive sequence variation at two effector loci (AvrP123, AvrP4) was found in M. lini isolates collected from across the native range of L. marginale in Australia, as well as in isolates collected from a second host, the cultivated species L. usitatissimum. A highly significant excess of nonsynonymous compared with synonymous polymorphism was found at both loci, suggesting that diversifying selection is important for the maintenance of the observed sequence diversity. Agrobacterium-mediated transient transformation assays were used to demonstrate that variants of both the AvrP123 and AvrP4 genes are differentially recognized by resistance genes in L. marginale. We further characterized patterns of nucleotide variation at AvrP123 and AvrP4 in 10 local populations of M. lini infecting the wild host L. marginale. Populations were significantly differentiated with respect to allelic representation at the Avr loci, suggesting the possibility of local selection maintaining distinct genetic structures between pathogen populations, whereas limited diversity may be explained via selective sweeps and demographic bottlenecks. 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Burdon</name><name sortKey="Dodds, Peter N" sort="Dodds, Peter N" uniqKey="Dodds P" first="Peter N" last="Dodds">Peter N. Dodds</name><name sortKey="Lawrence, Gregory J" sort="Lawrence, Gregory J" uniqKey="Lawrence G" first="Gregory J" last="Lawrence">Gregory J. Lawrence</name><name sortKey="Linde, Celeste C" sort="Linde, Celeste C" uniqKey="Linde C" first="Celeste C" last="Linde">Celeste C. Linde</name><name sortKey="Thrall, Peter H" sort="Thrall, Peter H" uniqKey="Thrall P" first="Peter H" last="Thrall">Peter H. Thrall</name><name sortKey="Van Der Merwe, Marlien" sort="Van Der Merwe, Marlien" uniqKey="Van Der Merwe M" first="Marlien" last="Van Der Merwe">Marlien Van Der Merwe</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Barrett, Luke G" sort="Barrett, Luke G" uniqKey="Barrett L" first="Luke G" last="Barrett">Luke G. Barrett</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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